How do we calculate COI?

There’s been some discussions recently as to why iwdb shows different (lower) values of inbreeding than some other systems. We would like to take the opportunity to explain how we calculate Coefficients of Inbreeding (COI), how that differs from Wright’s formula for doing the same thing, and why we’ve chosen the method we have.

When describing any inbreeding, it’s necessary to calculate the distance between all ancestors being present on both sides of the pedigree. This is done through a normal path-counting method, counting the distance in generations from the appearance on the sire-side and the appearance on the dam-side.

This is what IWDB does. When Sewell Wright constructed his formula in 1922, he also added that the COI of the common ancestor itself should be added to the calculation. This is the way it’s done in most pedigree-programs, but not in IWDB. Thus IWDB will report a somewhat smaller

There are technical reasons for our choice to omit additions of common ancestor COI. IWDB calculates COI on anything from 3 through 10 generations. In order to include ancestors COI, we would have to store the COI of all dogs that were bred from in the database in 3-10 generations. In order to provide accurate and fast calculations for trial matings, we would have to include all dogs in the database in this dataset as well as COI of all trial matings. The COI would have to be recalculated for all descendants any time we add an ancestor to the dataset. All of this is very time consuming. Typically, in the neigbourhood of 30 minutes each time it’s done.

What difference does it make? It varies a lot and all depends on the ancestors, their inbreeding and their usage. IWDB will normally report a bit lower COI (Anywhere between 1-3 percentage points) than other programs.

We are comparing apples to apples, though, so when comparing to breed averages, the calculations done are the same.

Contribution of blood

We have added Contribution of Blood as a value in the ancestor-listings of IWDB. Interpreting these data is something some people are very used to, while it’s unknown territory for others.

Contribution of blood is an estimation of the genetic contribution made to an individual by a specific ancestor. It is given as a percentage. The base theory is that each of the parents contribute half of the genetic makeup for the offspring (50%). Each grandparent contribute a quarter (25%) each, and so on.

For each generation, the total contribution totals 100%. For each generation we go back, any single ancestor’s genetic contribution thus gets less important. A dog 10 generations back contributes less than a tenth of 1% of its genetic material to the present generation.

The contribution of blood should not be interpreted as giving a precisely accurate measure of the genetic contribution in a hound. In these calculations, the whole of generation 10 seems to be as influential as the parents. That’s not how these things work.

Look at the contribution table below, there is a cumulative effect of each generation. Each parents 50% contribution is made up of 25% from each grandparent, which is made up of 12.5% from each great-grandparent, and so on back through the generations.

Contribution-table

GenerationContribution pr appearance
150%
225%
312.5%
46.125%
53.063%
61.563%
70.781%
80.391%
90.195%
100.098%

How can I use this?

These values are useful to see which dog is more influential in a certain breeding-program. This is especially true if the breeder is linebreeding. Then one of the more interesting questions is “who are you linebreeding on?”. The contribution of blood will give a good answer to this question. Look for the hounds with high percentage in common ancestors.

If a dog’s parent is also a grandparent on the other side of the pedigree then we can see that this ancestor has contributed 75% of the genetic make up of the dog. It’s not so easy to calculate when an individual appears twice in the 4th generation, 3 times in the fifth generation and once in the 6th generation. Or if she appears 12 times in the 8th generation, 8 times in the 9th and 7 times in the tenth. It’s a very handy way to see genetic influence without having to calculate all of this yourself. When we get way back in the pedigree, it’s quite common that certain dogs appear many times in many generations, making it hard to calculate. Now IWDB can tell you how much genetic influence that ancestor has on your own dog.

The popular sire syndrome

There’s been a lot of discussion in the worldwide Irish Wolfhound community on the popular sire syndrome, especially related to Quincy of Kilmara, his parents and siblings.

The popular sire syndrome is usually used to describe the situation where one stud dog and his offspring has become so popular that it’s very hard or impossible to avoid him in any given pedigree or mating. Most or all dogs alive will be related to him in some way. This constitutes a genetic bottleneck, where this dog’s genes are spread throughout the whole worldwide population.

Historic popular sires

There’s been a number of popular sires in Irish Wolfhound history, where some reasonably popular dogs born in the 70s now being in most pedigrees. The most well-known example of these is Eaglescrag Lysander, born in 1975. Almost all dogs born from 1999 and onwards are related to him. The last litter born without him in the pedigree was born in Canada in 2012. Other well known and historic examples are Clonboy of Ouborough and Sanctuary Rory of Kihone who both have a very special place in our breed history as important dogs around World War II. They are both present in the pedigree of every Irish Wolfhound born in the last 50 years or so.

Eaglescrag Lysander
Eaglescrag Lysander, now present in almost every pedigree of Irish Wolfhounds alive today.
The development of Eaglescrag Lysander’s influence on the breed

How do they occur?

The popular sire syndrome occurs when there’s either very few individuals to breed from, or one dog produces excellent progeny who are then used a lot. Not all dogs who produce a lot of litters will become a popular sire and some dogs do eventually become very popular through the quality of their progeny even though they didn’t breed that much.

A good example of this is our 100+ founders, who are all present in all modern Irish Wolfhound pedigrees. It’s thus impossible to breed an Irish Wolfhound without the blood from great danes, borzois, the numerous deerhounds, the one mastiff or one tibetan dog used in resurrecting the breed more than a century ago. They’ve all gone on to become involved in every Irish Wolfhound pedigree. This has occured naturally, mainly through the breed bottlenecks around World War I.

Wolf-tibetan dog
Wolf – the tibetan dog present in every Irish Wolfhound pedigree for almost 100 years

In IWDB.ORG, there’s a special tool (Under the offspring-pane) to look at the influence every dog has had historically. These graphs really show how a popular sire syndrome evolves over time. There seems to be a point-of-no-return where a dog who passes that point eventually will become a popular sire given enough time and generations. One might argue that this really won’t be a problem unless each dog is reasonably closely related to the dog in question. With Sanctuary Rory of Kihone it took only four generations before he was present in the pedigree of more than 90% of dogs being born. Thus he had a major influence because of the short timespan used to become dominant. With Eaglescrag Lysander it took six generations to reach that point. The same goes for Quincy of Kilmara who passed 90% in 2016. Others are slower in gaining influence, like Wild Eagle Saxon-StClair, born in 1980 and now approaching 90% population coverage, nine generations later.

Influence of Sanctuary Rory of Kihone
Sanctuary Rory of Kihone very quickly got a presence in every Irish Wolfhound pedigree

Some mathematics

Some would argue that the popular sire syndrome really doesn’t matter unless the sire in question is present in all 5 or 6 generation pedigrees. The tibetan hound Wolf had his first litter in 1892, some 31 generations ago. Looking at the pure mathematics of this, these 31 generations would include some 4 billion individuals. It’s extremely unlikely that any dog born at that time who had descendants over a few generations wouldn’t be present in all pedigrees today. Even if Wolf is present 4 million times in your 31 generation pedigree, he would still only have contributed 1/10 of a percent of the gene material in your dog. His influence is thus reduced through the many generations passed and the influence of other dogs.

Does it all matter?

Is the popular sire syndrome really important? Yes, it is. As a breed we need to make sure there’s a huge variation in the dogs being used in breeding. If we all use the same sires or allow them to be overused, we will lose genetic variation, be more vulnerable to genetic diseases and generally have a less diverse breed than we do today. It’s the responsibility of every breeder to take care of our breed and make sure we don’t get stuck in genetic bottlenecks. It’s also the responsibility of every owner of males to make sure they don’t become matadors. A matador is a very popular stud dog, generally used to sire more than 5% of the population in any given region. Creating matadors will increase the likelihood of him becoming dominant in pedigrees over a short period of time. Special care should be taken when semen is exported or stud-dogs are being used abroad as these may quickly be influential around the world.

Given the new tool in iwdb, breeders may see how any dog in a trial mating has influenced the breed and take appropriate action as they see fit.

Blog post written by Per Arne Flatberg

All lives matter

All Irish Wolfhound-lives matter. If you’ve ever had an Irish Wolfhound, we encourage you to add lifespan-info to The Irish Wolfhound database at iwdb.org.

The database has pedigrees of around 160,000 Irish Wolfhounds. There’s lifespan-information on more than 6,000 of them. That number is rapidly increasing. This information allows new knowledge to be gained about diseases and longevity in Irish Wolfhounds. In addition, it helps breeders make informed choices when selecting breeding stock. We need your help in getting info about your deceased dog in the database. Lifespan info is shown on the pedigrees and there’s also a listing of average lifespan for each dog’s pedigree under the ancestors-pane.

How can I help?

By submitting lifespan-information to iwdb.org, information will be archived and published. The information will also be used to calculate longevity-info in the breed and in pedigrees. In order to get a complete picture, we need information on all dogs, not just those that have been bred from.

There are several ways you may submit info:

  1. Send us an email at info@iwdb.org or a message on Facebook. We need the dogs name, date of death and cause of death if available. If you don’t have the exact date, we will put in an approximated date if you remember how old it got.
  2. Look up the dog in iwdb.org. If you are a registered user, you may add info with Correct/Append to this pedigree. If you’re not, feel free to use the button “Report a problem” to send us the information mentioned above.

Visualising inbreeding

Paying attention to inbreeding levels is important for breeders, breed bodies and buyers.

Kennel Clubs worldwide recommend low inbreeding levels. They want to combat genetic diseases and inbreeding depression in breeds. Recommendations vary a bit. We find the recommendations of The Kennel Club to be quite sensible with some adjustments.
[…]where possible, breeders should produce puppies with an inbreeding coefficient which is at, or below, the annual breed average and ideally as low as possible.
The point being made is that we need to breed below current levels in order to not increase inbreeding in general. We believe a one year perspective might be a little low as it’s vulnerable to fluctuations based on just a few litters, and have chosen to work on the last ten years instead. We also find the idea of just working with national averages a bit outdated, and have chosen to use the whole world for our baseline data.

Visualisation

We struggled a bit on how we could show inbreeding understandably. Could we use a diagram? Maybe a combination of line and bar graphs? Maybe use a table?

Graph showing a sample litter and the level of inbreeding compared to the breed average
We chose to provide a “speedometer” type dial to show levels of inbreeding. If the arrow points to the green area, the inbreeding levels are below average. Yellow is around average values. The red is above average values. The max-value is the highest recorded coefficient of inbreeding in that period. It should thus be quite easy to see if a dog is more or less inbred than the average. We also provide a description, stating what average values are at.

We’ve previously created a handy table on inbreeding in the Irish wolfhound population.

Status on pedigree-data

The Irish wolfhound database is by no means complete. Although our goal is to record the pedigree of every Irish wolfhound ever, we are not able to reach that goal. The main reason is that we don’t have access to all Kennel Club registers, and not all Kennel Club registers are complete. If you are familiar with the wolfhound population in one of the countries where our coverage is less than complete, we would be very grateful if you would help us by sharing your data.

Here’s the status on countries where we have registered irish wolfhounds as of december 2017:

  • Argentia
    Probably incomplete
  • Australia
    Complete through 2017
  • Austria
    Complete from 2009 through 2017, incomplete data before that
  • Belgium
    Incomplete
  • Bulgaria
    Incomplete
  • Canada
    Probably complete
  • Chile
    Incomplete
  • Czech Republic
    Complete
  • Denmark
    Complete
  • Estonia
    Complete
  • Finland
    Complete
  • France
    Complete
  • Georgia
    Incomplete
  • Germany
    Complete through 2015
  • Hungary
    Incomplete
  • Ireland
    Incomplete
  • Israel
    Incomplete
  • Italy
    Complete
  • Japan
    Complete
  • Latvia
    Complete
  • Lithuania
    Complete
  • Luxembourg
    Probably complete
  • Mexico
    Incomplete
  • Moldova
    Unknown
  • Namibia
    Incomplete
  • Netherlands
    Complete
  • New Zealand
    Complete
  • Norway
    Complete
  • Poland
    Incomplete
  • Portugal
    Incomplete
  • Romania
    Incomplete
  • Russia
    Incomplete
  • Serbia
    Incomplete
  • Slovakia
    Complete
  • Slovenia
    Incomplete
  • South Africa
    Incomplete
  • Spain
    Incomplete
  • Sweden
    Complete
  • Switzerland
    Incomplete
  • Uganda
    Incomplete
  • Ukraine
    Incomplete
  • United Kingdom
    Complete
  • United States
    Incomplete
  • Zimbabwe
    Incomplete

Private notes

Private notes and annotations is a new feature of iwdb.org. It’s main use is for annotating pedigrees with information that may not be public or doesn’t fit in the iwdb.org framework.

What kind of info fits?

Different people will use private notes for different things. It all comes down to what’s important for you. Here’s some ideas as to what info might fit you:

  • Show results
  • Your own impression of the dog
  • Temperament
  • Known diseases and treatments
  • Confidential information like age and cause of death if not known in iwdb
  • Veteran-status
  • Semen-storage

The list could be made much longer, but we do hope you get the idea.

How is the information protected?

We take your privacy very seriously and acknowledge that private information is just that: Private information. To ensure that, all information you enter is encrypted with a special key that itself is also encrypted. Without the original key, information is gibberish. We are using state of the art encryption techniques, which means the information is safe from most intruders. Security is always a compromise between practicality and security however, and no information entered online is completely safe.

How do I add and edit info?

To use this feature you have to be logged in as a registered user of iwdb.org. If you are, adding and editing info is easy through the small text labeled Add Private info underneath each dog’s listing. Click it, and an inline editing window will show up. When you’re done, just click save. You are free to use formatting and HTML in these listings.

If you’re not a registered user, we suggest you become one. It’s free and easy. Just click the button Register/Login, choose register and enter details. You will receive a confirmation-mail which asks you to confirm. Once done, you are logged in and may start using private notes